Yang Laboratory

Selected Publications

Liu Y, Molchanov V, Yang T. 2021. Enzymatic machinery of ubiquitin and ubiquitin-like modification systems in chondrocyte homeostasis and osteoarthritis. Curr Rheumatol Rep 23:62.

Wang W, Wang M, Ruan Y, Tan J, Wang H, Yang T, Li J, Zhou Q. 2019. Ginkgolic acids impair mitochondrial function by decreasing mitochondrial biogenesis and promoting FUNDC1-dependent mitophagy. J Agric Food Chem 67(36):10097–10106.

He Y, Shi J, Nguyen QT, You E, Liu H, Ren X, Wu Z, Li J, Qiu W, Khoo SK, Yang T, Yi W, Sun F, Xi Z, Huang X, Melcher K, Min B, Xu HE. 2019. Development of highly potent glucocorticoids for steroid-resistant severe asthma. Proc Natl Acad Sci U S A 116(14):6932–6937.

Lu D, Li J, Liu H, Foxa GE, Weaver K, Li J, Williams BO, Yang T. 2018. LRP1 suppresses bone resorption in mice by inhibiting the RANKL-stimulated NFκB and p38 pathways during osteoclastogenesis. J Bone Miner Res.

Maupin K, Weaver K, Bergsma A, Christie C, Zhong Z, Yang T, Williams BO. 2018. Enhanced cortical bone expansion in Lgals3-deficient mice during aging. Bone Res 6(7).

Liu H, Li J Lu D, Li J, Liu M, Williams BO, Li J, Yang T. 2018. Ginkgolic acid, a sumoylation inhibitor, promotes adipocyte commitment but suppresses adipocyte terminal differentiation of mouse bone marrow stromal cellsSci Rep 8:2545.

Li J, Lu D, Dou H, Liu H, Weaver K, Wang W, Li J, Yeh ETH, Williams BO, Zheng L, Yang T. 2018. Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway. Nat Commun. 9:143.   

Yang T, Williams BO. 2017. Low-density lipoprotein receptor-related proteins in skeletal development and disease. Physiol Rev 97(3):1211-1228. 

Li J, Lu D, Liu H, Williams BO, Overbeek P, Lee B, Zheng L, Yang T. 2017. Deficiency of SCLT1 causes cystic kidney by activating ERK and STAT3 signalingHum Mol Genet 26(15):2949–2960.

Grafe I, Alexander S, Yang T, Lietman C, Homan EP, Munivez E, Chen Y, Jiang MM, Bertin T, Dawson B, Asuncion F, Ke HZ, Ominsky MS, Lee B. 2016. Sclerostin antibody treatment improves the bone phenotype of Crtap-/- mice, a model of recessive Osteogenesis ImperfectaJ Bone Miner Res 31(5):1030–1040.    

He Y, Shi J, Yi W, Ren X, Gao X, Li J, Wu N, Weaver K, Xie Q, Khoo SK, Yang T, Huang X, Melcher K, Xu HE. 2016. Discovery of a highly potent glucocorticoid for asthma treatment. Cell Disc doi:10.1038/celldisc.2015.35.      

Lu L, Harutyunyan K, Jin W, Wu J, Yang T, Chen Y, Joeng KS, Bae Y, Tao J, Dawson BC, Jiang MM, Lee B, Wang LL. 2015. RECQL4 regulates p53 function in vivo during skeletogenesisJ Bone Miner Res 30(6):1077–1089          

Chen S, Grover M, Sibai T, Black J, Rianon N, Rajagopal A, Munivez E, Bertin T, Dawson B, Chen Y, Jiang MM, Lee B, Yang T, Bae Y. 2015. Losartan increases bone mass and accelerates chondrocyte hypertrophy in developing skeletonMol Genet Metab 115(1):53–60.      

Grafe I, Yang T, Alexander S, Homan EP, Lietman C, Jiang MM, Bertin T, Munivez E, Chen Y, Dawson B, Ishikawa Y, Weis MA, Sampath TK, Ambrose C, Eyre D, Bächinger HP, Lee B. 2014. Excessive transforming growth factor-β signaling is a common mechanism in osteogenesis imperfecta.  Nat Med 20(6):670–675.

Yang T, Grafe I, Bae Y, Chen S, Chen Y, Bertin TK, Jiang M-M, Ambrose CG, Lee B.  2013. E-selectin ligand 1 regulates bone remodeling by limiting bioactive TGF-β in the bone microenvironment.  Proc Natl Acad Sci USA 110(18):7336–7341.    

Chen S, Tao J, Bae Y, Jiang MM, Bertin TK, Chen Y, Yang T, Lee B. 2012. Notch gain of function inhibits chondrocyte differentiation via Rbpj-dependent suppression of Sox9J Bone Miner Res 28(3):649–659.     

Bae Y, Yang T*, Zheng HC*, Campeau P, Chen Y, Bertin T, Dawson B, Munivez E, Tao J, Lee B. 2012. miRNA-34c regulates Notch signaling during bone developent.  Hum Mol Genet 21(13):2991–3000.      
*Contributed equally

Keller B, Yang T, Chen Y, Munivez E, Bertin TK, Zabel B, Lee B. 2011. Interaction of TGF- β and BMP signaling pathways during chondrogenesisPLoS One 6(1):e16421.      

Yang T, Mendoza RL, Lu H, Li K, Tao J, Shah R, Keller B, Jiang M-M, Chen Y, Bertin TK, Dabovic B, Engin F, Rifkin DB, Hicks J, Jamrich M, Beaudet AL, Lee B. 2010. E-Selectin Ligand 1 regulates growth plate homeostasis by inhibiting the intracellular processing and secretion of mature transforming growth factor βJ Clin Invest 120(7):2474–2485.    

Tao J, Chen S, Yang T, Dawson B, Munivez E, Bertin T, Lee B.  2010. Osteosclerosis due to Notch gain of function is solely Rbpj-dependentJ Bone Miner Res 25(10):2175–2183.     

Mao J, Yang T, Gu Z, Heird WC, Finegold MJ, Lee B, Wakil SJ. 2009. aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose tissues under lipogenic conditions.  Proc Natl Acad Sci USA 106(41):17576–17581.     

Jiang M, Gao Y, Yang T, Zhu X, Chen J.  2009. Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1FEBS Lett 583(13):2171–2178.

Engin F, Yao Z*, Yang T*, Zhou G, Bertin TK, Jiang MM, Chen Y, Wang L, Zheng H, Sutton RE, Boyce BF, Lee B. 2008. Dimorphic effects of Notch signaling in bone homeostasisNat Med 14(3):299–205.
*Contributed equally

Gao Y, Jiang M, Yang T, Ni J, Chen J. 2006. A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteinsCell Res 16(6):539–547.  

Chen Q, Liang D, Yang T, Leone G, Overbeek PA. 2004. Distinct roles of individual E2Fs in induction of cell cycle entry in postmitotic lens fiber cells of transgenic miceDev Neurosci 26(506):435–445.

Yang T*, Liang D, Koch PJ, Hohl D, Kheradmand F, Overbeek PA*. 2004. Epidermal detachment, desmosomal dissociation and destabilization of corneodesmosin in Spink5-/- miceGenes Dev 18(19):2354–2358.     
*Corresponding authors

Yang T, Gao Y-K, Chen J-Y.  2002. KIAA0202, a human septin family member, interacting with hPFTAIRE1Acta Biochem Biophys Sin 34(4):520–525.  

Yang T, Chen J-Y.  2001. Identification and cellular localization of human PFTAIRE1Gene 267(2):165–172.      

Book chapters

Yang T, Gover M, Joeng K, Lee B. 2017. Fetal and neonatal bone development. Primer on the metabolic bone diseases and disorders of mineral metabolism. 9th ed. American Society for Bone and Mineral Research.

Yang T, Gover M, Joeng K, Lee B. 2013. Fetal and neonatal bone development.  Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8th ed. Wiley-Blackwell.